慢性阻塞性肺病患者急性期与缓解期血细胞分布宽度及D-二聚体变化研究

Study on changes of blood cell distribution width and D-dimer in patients with chronic obstructive pulmonary disease

目的探讨慢性阻塞性肺病患者急性期与缓解期血细胞分布宽度及D-二聚体变化情况在慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)疾病发展过程中的动态变化及临床意义。方法选取我院收治的60例慢性阻塞性肺疾病患者,根据其病程分为急性期组和缓解期组,各30例,同时选取同期健康体检者30例作为对照组。取所有患者的血浆进行血细胞体积(erythrocyte mean corpuscular volume,MCV)及分布宽度(red blood cell volume distriution width,RDW)及D-二聚体的测定。结果急性期组及缓解期组的MCV及RDW明显高于健康对照组(P<0.05),急性期组MCV及RDW明显高于缓解期组(P<0.05),急性期与缓解期RDW呈正相关(r=0.717,P=0.000),急性期与缓解期MCV呈正相关(r=0.902,P=0.000)。急性期组及缓解期组的D-二聚体水平明显高于健康对照组(r=0.727,P<0.05),急性期组D-二聚体水平明显高于缓解期组(P<0.05),且急性期与缓解期组D-二聚体呈正相关(P<0.05)。结论慢性阻塞性肺病患者在急性期与缓解期血细胞分布宽度及D-二聚体水平均有升高,急性期患者升高更为明显。

Objective To investigate the changes of blood cell distribution width and D-dimer in patients with chronic obstructive pulmonary disease.Methods 60 cases with chronic obstructive pulmonary disease were selected and according to the course of disease were divided into two groups.30 healthy people were selected to be the control group.MCV, RDW and D-dimer were detected and compared.ResuIts Compared with the control group, MCV and RDW of acute phase group and remission stage group are higher(P<0.05), compared with the remission stage group, MCV and RDW of acute phase group were higher(P<0.05), and RDW and MCV in the acute stage group were positively correlated with the remission stage group (r=0.717, 0.902, P<0.05).Compared with the control group, D-dimer of acute phase group and remission stage group were higher(P<0.05), compared with the remission stage group, D-dimer of acute phase group were higher(P<0.05), and D-dimer in the acute stage group were positively correlated with the remission stage group (r=0.727, P<0.05).ConcIusion The distribution of blood cell distribution width and D-dimer levels in patients with chronic obstructive pulmonary disease in acute stage and remission stage group were increased, and the increasing of patients with chronic obstructive pulmonary disease in the acute stage is more obvious.