植物性雌激素对子宫肌瘤合并缺铁性贫血患者血清激素水平、NOS及氧化应激产物影响

Effect of plant estrogen on serum hormone levels,NOS and oxidative stress products in patients with uterine fibroids with iron deficiency anemia

目的探讨植物性雌激素对子宫肌瘤合并缺铁性贫血患者血清激素水平、NOS及氧化应激产物的影响。方法收集子宫肌瘤患者80例,根据用药不同随机分为实验组和对照组,每组各40例,2组患者给与贫血纠正治疗,对照组给与米非司酮口服,实验组在对照组基础上给与植物性雌激素治疗,连续12周后对患者的血清性激素、NOS、SOD、MDA水平进行检测。结果治疗后,与对照组相比,实验组血清性激素各指标均较低(P<0.05),血清NOS水平较高(P<0.05),血清SOD水平较高(P<0.05),MDA水平较低(P<0.05)。结论植物性雌激素能够通过改善患者血清激素水平、NOS及氧化应激产物水平治疗子宫肌瘤,对临床具有指导意义。

Objective To investigate the effect of plant estrogen on serum hormone levels, NOS and oxidative stress products in patients with uterine fibroids with iron deficiency anemia.Methods 80 cases of hysteromyoma patientswith uterine fibroids with iron deficiency anemia were selected, according to the different medication were randomly divided into experiment group and control group,40 cases in each group.Two groups were treated with anemia correction , mifepristone oral ,and the experiment group were treated on the base of the control group with plant estrogen, 12 weeks for a course.serum sex hormone, NOS, SOD and MDA level were detected.ResuIts Compared with the control group, the indexes of patients in the experimental group were lower(P<0.05), level of serum NOS were higher(P<0.05), level of serum SOD were higher(P<0.05), level of serum MDA were lower ( P<0.05 ) .ConcIusion Plant estrogen can improve the serum levels of serum hormone, NOS and oxidative stress levels of the treatment of uterine fibroids, worthy of clinical promotion.