甲硝唑片联合苦参凝胶治疗细菌性阴道炎的临床疗效分析

Curative efficacy analysis for metronidazole tablets combined with sophora gel in treatment of bacterial vaginitis

目的探讨甲硝唑片联合苦参凝胶治疗细菌性阴道炎(bacterial vaginitis,BV)的临床疗效。方法将87例细菌性阴道炎患者按照随机数字表法分为研究组(45例)和对照组(42例)。对照组口服甲硝唑片(400 mg,2次/天),连服7 d;研究组在对照组的基础上加用苦参凝胶阴道置入治疗,连续治疗7 d。比较2组患者治疗前后的阴道分泌物白细胞酯酶试验阳性率及治疗1年内的复发率。结果治疗7 d后,2组患者的白细胞酯酶(leucocyte esterase,LE)阳性率均较治疗前显著下降,且研究组下降更显著(P<0.05);研究组治疗的总有效率为95.6%,显著高于对照组78.6%(P<0.05)。研究组1年内复发率为6.7%,显著低于对照组26.2%(P<0.05)。结论甲硝唑片联合苦参凝胶能显著降低细菌性阴道炎患者的LE阳性率及复发率,提高临床疗效。

Objective To observe the clinical efficacy of metronidazole tablets combined with sophora gel in treatment of bacterial vaginitis ( BV) . Methods Eighty-seven cases of BV patients were randomly divided into the study group(45cases) and the control group(42cases).The control group was given metronidazole tablets (400 mg, two times a day), oral for seven days, while the study group was given sophora gel (vaginal implantation) on the basis of control group.Seven days as a course of treatment.Pared the leukocyte esterase test positive rate in vaginal fluid and the recurrence rate within a year of the two groups before and after treatment.ResuIts After 7 days’treatment, the positive rate of leukocyte esterase (LE) in two groups were all significantly declined, which was more significant in the study group (P<0.05);the total effective rate of the study group was 95.6%, which was significantly higher than that of the control group 78.6%(P<0.05).The recurrence rate within a year of the study group was 6.7%, which was significantly lower than that of the control group 26.2%( P<0.05 ) .ConcIusion The therapy of metronidazole tablets combined with sophora gel in treating BV can significantly decline the LE positive rate and recurrence rate, and improve the clinical curative efficacy as well.