多指标综合评分法优选清热解毒口服液的提取工艺

Optimize the extraction process of Qingrejiedu oral liquid by multi-index comprehensive evaluation

目的优选清热解毒口服液最佳提取工艺。方法以加水量、提取时间、提取次数和含醇百分率为考察因素,每因素设计3个水平,以黄芩苷、绿原酸和栀子苷转移率及浸膏得率为指标,进行加权综合评价,用L9(34)正交表安排试验。结果清热解毒口服液最佳的提取工艺为加8倍量水提取3次,每次1h,含醇百分率为70%。结论验证试验表明通过正交试验得到的清热解毒口服液提取工艺设计合理,结果可靠,提取效果较好,具有较高的应用价值。

Objective To optimize the extraction techique for Qingrejiedu oral liquid.Methods The amount of water, extraction time , extraction times and alcohol content were used as inspection factor, 3 levels per factor, with baicalin, chlorogenic acid , geniposide transfer rate and extraction rate as indexes,carries on Weighted comprehensive evaluation,the optimal extractin were screened by L9 (34 ) orthogonal test.ResuIts The optimal extraction condition of Qingrejiedu oral liquid were as follow:extraction for 3 times and 1h each time with 8-fold amount of water and 70% alcohol. ConcIusion Through the orthogonal test, the extraction process of Qingrejiedu oral liquid is designed reasonably, the result is reliable, and the extraction effect is good, and has higher application value.