不同基因型耐药分析系统在HIV耐药预测中的应用

Discordances between interpretation algorithms for genotypic resistance in prediction of human immunodeficiency virus resistance

随着高效抗逆转录病毒治疗的持续进行,部分人类免疫缺陷病毒(HIV)感染者的体内出现大量耐药毒株,产生的耐药性导致治疗效果大幅下降甚至治疗失败。生物信息学平台的基因型耐药分析技术,是预测上述HIV耐药性的有力工具,决定抗病毒治疗的成败。本文从基因型耐药分析的原理、特点等角度出发,对目前国际上流行的主要HIV基因型耐药分析系统的优缺点以及基因型耐药预测的影响因素和改进措施等方面进行综述,以期为不同基因型耐药分析系统在我国的合理应用提供借鉴。

As highly active anti-retroviral therapy continues, large numbers of drug-resistant strains appeared in human immunodeficiency virus ( HIV) infectors, which always leads to a decline of treatment results or even a treatment failure.The genotypic resistance analysis technique of the bioinformatics is a powerful tool to forecast the HIV resistance and also determines the success or failure of antiviral therapy.This review will be focus on the advantages and disadvantages, influence factor of the genotype resistance prediction and improve measure of the primary HIV drug resistance genotype interpretation system, depending on the principle and characteristics of the genotypic drug resistance analysis as the breakthrough point, in order to provide guidance for reasonable application of different genotypes drug resistance analysis system in China.