银杏叶提取物对帕金森患者血清黑质DMT1、葡萄糖调节蛋白75及神经功能的影响研究

Effect of Ginkgo biloba extract on serum DMT1,grp75 and neurological function in patients with Parkinson disease

目的探讨银杏叶提取物对帕金森患者血清黑质二价金属离子转运蛋白(divalent metal transporter1,DMT1)、葡萄糖调节蛋白75(glucose regulated protein 75,grp75)及神经功能的影响。方法帕金森患者38例,根据用药不同分为对照组和实验组,每组各19例,对照组患者给予多巴丝肼片,实验组在对照组的基础上给予银杏叶提取物片,治疗连续4周。治疗结束后,对所有患者黑质DMT1、grp75及认知功能进行检测。结果与治疗前相比,治疗后2组患者的黑质DMT1水平较低(P<0.05);与对照组相比,实验组患者治疗后黑质DMT1水平较低(P<0.05)。与治疗前相比,治疗后2组患者的grp75水平较高(P<0.05),与对照组相比,实验组患者治疗后grp75水平较高(P<0.05)。与治疗前相比,治疗后2组患者的Mo CA评分较高(P<0.05),HAMD评分较低(P<0.05);与对照组相比,实验组患者治疗后Mo CA评分较高(P<0.05),HAMD评分较低(P<0.05)。结论银杏叶提取物能够显著降低帕金森患者黑质DMT1水平,升高grp75水平,改善认知功能。

Objective To investigate the effect of Ginkgo biloba extract on serum divalent metal transporter1( DMT1),glucose regulated protein75( grp75) and nerve function in patients with Parkinson disease. Methods 38 cases of patients loith parkinson disease according to different drugs were divided into experimental group and control group,19 cases in each group. Control group was treated with levodopa and Benserazide tablet,experimental group on the basis of control group,was given Ginkgo biloba extract tablets,treatment for 4 weeks. After treatment,DMT1,grp75 and cognitive function of all patients in substantia nigra were detected. Results Compared with before treatment,two groups of patients with lower DMT1 level( P < 0. 05),compared with control group,experimental group of patients with lower DMT1 levels( P < 0. 05). Compared with pre-treatment,two groups of patients grp75 level was higher( P < 0. 05),compared with control group,experimental group after treatment grp75 level was higher( P < 0. 05). Compared with before treatment,the two groups of patients with Mo CA scores were higher( P < 0. 05),HAMD scores were lower( P < 0. 05). Compared with control group,experimental group after treatment Mo CA scores were higher( P < 0. 05),HAMD scores were lower( P < 0. 05). Conclusion Ginkgo biloba extract can significantly reduce the level of DMT1 in the substantia nigra of Parkinson patients,increase the level of grp75,and improve the cognitive function.