肺心病患者右室肥厚与维生素D、房颤及NT-proBNP的关系

Correlation of right ventricular hypertrophy and vitamin D,atrial fibrillation and NT-proBNP in patients with pulmonary heart disease

目的探讨肺心病患者右室肥厚与维生素D、房颤及NT-proBNP的关系。方法选取河北唐山市人民医院收治的肺心病患者40例,根据是否伴有右室肥厚分为肥厚组以及非肥厚组。对2组患者进行超声心动图、血清25羟维生素D、24 h动态心电图以及NT-proBNP水平检测,并对其与右室肥厚程度之间的相关性关系进行分析。结果肥厚组患者的右室前壁厚度(right ventricular anterior wall,RVAW)及右室舒张末期内径(right ventricular diastolic diameter,RVDd)大于非肥厚组(P<0.05)。肥厚组血清25羟维生素D水平显著低于非肥厚组(P<0.05),25羟维生素D水平与右心室前壁厚度无相关性(r=-0.189,P=0.424)。房颤组患者右心室前壁厚度显著大于非房颤组(P<0.05)。右心室前壁厚度与房颤次数无相关性(r=0.178,P=0.452)。肥厚组血清NT-proBNP水平显著高于非肥厚组(P<0.05),右心室前壁厚度与血清NT-proBNP水平无相关性(r=-0.105,P=0.660)。结论肺心病患者右室肥厚患者血清维生素D水平较低,NT-proBNP水平较高,发生房颤患者右心室前壁厚度较大,但无相关性,推测其与样本数量较少有关。

Objective To investigate correlation of right ventricular hypertrophy and vitamin D , atrial fibrillation and NT-proBNP in patients with pulmonary heart disease.Methods 40 cases of pulmonary heart disease were selected, according to whether the right ventricular hypertrophy or not, and divided into hypertrophy group and non hypertrophy group.Echocardiography, serum 25 hydroxy vitamin D, 24 h dynamic electrocardiogram and NT-proBNP level were detected, and the correlation were detected between the right ventricular hypertrophy and influence factors.ResuIts The right ventricular anterior wall ( RVAW) and right ventricular diastolic diameter ( RVDd) in hypertrophy group were significantly greater than those in non hypertrophy group (P<0.05).The serum 25 hydroxy vitamin D levels in hypertrophy group was lower than that in non hypertrophy group (P<0.05), but there was no significant correlation of right ventricular hypertrophy and 25 hydroxy vitamin D levels(r=-0.189,P=0.424).The thickness of right ventricular anterior wall in atrial fibrillation group was greater than that in non atrial fibrillation group (P<0.05), but there was no significant correlation of right ventricular hypertrophy and atrial fibrillation times(r=0.178,P=0.452).Serum NT-proBNP levels in hypertrophy group was higher than that in non hypertrophy group (P<0.05), but there was no significant correlation of right ventricular hypertrophy and serum NT-proBNP levels(r=-0.105, P=0.660).ConcIusion Patients with right ventricular hypertrophy of pulmonary heart disease who has a lower serum 25 hydroxy vitamin D level and a higher NT-proBNP level.Patients with atrial fibrillation has a thicker RVAW.However, there was no correlation of above influence factors.