瑞格列奈联合珍芪降糖胶囊对老年2型糖尿病患者β细胞功能的影响研究

Effect of repaglinide combined with Zhenqi Jiangtang Capsules on β cell function in elderly patients with type 2 diabetes mellitus

目的探讨瑞格列奈联合珍芪降糖胶囊对老年2型糖尿病患者β细胞功能的影响。方法收集海口市人民医院海港分院收治老年2型糖尿病患者60例,随机分为实验组和对照组,每组各30例。2组患者均给予控制饮食、适度运动等常规辅助治疗。对照组在此基础上给予瑞格列奈1 mg/次,1天3次,口服治疗;实验组在对照组基础上给予珍芪降糖胶囊4粒/次,1天3次,口服治疗,共治疗4周。治疗结束后,对所有患者的血糖水平、血清胰岛素水平、β细胞功能相关指数以及血脂情况进行检测。结果治疗后,与对照组比较,实验组患者餐后各时段血糖水平、Hb A1c水平及AUCg含量明显较低(P<0.05);实验组患者餐后30、60、120 min胰岛素水平均明显较高(P<0.05);实验组患者的HOMA-IR明显较低(P<0.05);实验组患者的IRG、AUCi、AUCi/AUCg明显较高(P<0.05);实验组患者的血清TC、TG、LDL水平均明显较低,血清HDL水平明显较高(P<0.05)。结论瑞格列奈联合珍芪降糖颗粒能够明显降低老年2型糖尿病患者的血糖、血脂水平,提高胰岛β细胞的功能,促进餐后胰岛素分泌,改善胰岛素抵抗。

Objective To analyse the effect of repaglinide combined with Zhenqi Jiangtang Capsules on β cell function in elderly patients with type2 diabetes mellitus. Methods 60 elderly patients were collected from harbour branch of Hainan provincial People's hospital,who were diagnosed with type 2 diabetes mellitus. All patients were randomly divided into experimental group and control group,30 cases in each group,2 groups of patients were given control diet,moderate exercise,and other conventional adjuvant therapy. Control group was treated with repaglinide orally on the basis of routine adjuvant treatment,1 mg / times,three times per day,experimental group were given Zhenqi Jiangtang Capsules based on the treatment in control group,4 grains / times,three times per day. Both groups were treated for 4 weeks,after the end of treatment,blood glucose levels,serum insulin levels,βcell function and serum lipids in all patients were detected. Results After treatment,compared with control group,the levels of blood glucose,Hb A1 c and AUCg in experimental group were significantly lower( P < 0. 05); the insulin levels 30 min,60 min,120 min after meal were significantly higher( P < 0. 05); the HOMA-IR of patients was significantly lower( P < 0. 05); IRG,AUCi and AUCi/ AUCg were significantly higher( P < 0. 05); the serum TC,TG,LDL levels were significantly lower,serum HDL levels were significantly higher( P < 0. 05). Conclusion Repaglinide combined with Zhenqi Jiangtang Capsules can significantly reduce the blood glucose and lipid levels in elderly patients with type 2 diabetes,improve the function of pancreatic beta cells,promote postprandial insulin secretion and improve insulin resistance.