脾氨肽口服冻干粉对小儿支原体感染肺炎伴哮喘患者尿视黄醇结合蛋白与C反应蛋白的影响研究

Effect of Spleen Aminopeptide Oral Lyophilized Powder on urinary RBP and CRP in children with mycoplasma pneumoniae infection and asthma

目的探讨脾氨肽口服冻干粉对小儿支原体感染肺炎伴哮喘患者尿视黄醇结合蛋白(retinol-binding protein,RBP)及C反应蛋白(C reactive protein,CRP)的影响效果。方法选取华中科技大学同济医学院附属普爱医院儿科收治的支原体肺炎伴哮喘患者60例,随机分为2组,其中对照组30例,予常规阿奇霉素抗炎治疗。实验组30例,予脾氨肽口服冻干粉治疗,2组均治疗7 d。正常组30例,选取健康儿童,不予任何治疗。治疗结束后,对比2组患儿尿视黄醇结合蛋白、尿素氮、肌酐、咳喘、哮鸣音症状恢复情况、C反应蛋白、血常规等水平变化情况。结果 2组患儿尿视黄醇结合蛋白、尿素氮、肌酐水平不同程度改善,且实验组尿视黄醇结合蛋白、尿素氮、肌酐较对照组明显降低(P<0.05);2组患儿咳喘、哮鸣音均不同程度改善,且实验组咳喘、哮鸣音、咳喘恢复时间、哮鸣音恢复时间较对照组改善明显(P<0.05);2组C反应蛋白及白细胞水平均不同程度改善,且实验组C反应蛋白和白细胞水平较对照组明显降低(P<0.05)。结论脾氨肽口服冻干粉能够明显改善患儿支原体肺炎感染状况,并缓解咳喘及哮鸣音症状,降低尿视黄醇结合蛋白及C反应蛋白等水平,改善因缺氧所致肾脏等功能损害。

Objective To investigate effect of Splenic Aminopeptide Oral Lyophilized Powder on urinary retinol-binding protein and CRP in children of mycoplasma pneumonia infection with asthma .Methods 60 cases were randomly divided into 2 groups, 30 cases of control group were given conventional anti-inflammatory treatment, azithromycin.30 patients of Experimental group were treated with Spleen Aminopeptide Oral Lyophilized Powder treatment, two groups were treated for 7 days.30 cases of healthy children were selected, given no any treatment.After treatment, urinary retinol binding protein, blood urea nitrogen, creatinine, cough, wheezing symptom recovery, C-reactive protein, blood and other changes were compared between two groups.ResuIts Two groups of children with urinary retinol binding protein, urea nitrogen, creatinine levels were improved in different degrees, and in experimental group, urinary retinol binding protein, urea nitrogen and creatinine decreased significantly compared with control group (P<0.05).Two groups of children with asthma and wheeze improved in different degrees, and cough wheeze, cough and wheeze recovery time of experimental group had more improvement than those of control group ( P<0.05 ) .Two group of C reactive protein and white blood cell level both improved in different degrees, and the experimental group of C reactive protein and white blood cell levels were significantly lower than those of control group (P<0.05).ConcIusion Spleen Aminopeptide Oral Lyophilized Powder can significantly improve the infection status of children with mycoplasma pneumonia, and relieve cough and wheeze symptoms, lower urinary retinol binding protein and C reactive protein level, improve kidney function damage induced by hypoxia.