利伐沙班与血塞通注射液联合应用对脊柱术后下肢深静脉血栓的作用

Effect of rivaroxaban compared with Xuesaitong injection on deep venous thrombosis of lower extremity after spinal surgery

目的探讨利伐沙班与血塞通注射液联合应用对脊柱术后下肢深静脉血栓(deep venous thrombosis,DVT)的作用。方法选取2013年5月~2015年5月承德市中心医院脊柱外科接受脊柱手术治疗的患者共90例,随机分为实验组和对照组,其中实验组45例,术后第1天给予利伐沙班+血塞通注射液至下地活动1周;对照组45例,术后第1天给予利伐沙班至下地活动1周。于术前、术后7~10 d及术后3个月行下肢血管多普勒超声检查,对所有患者的DVT和肺栓塞发生情况进行统计。结果实验组在观察时间内共出现DVT患者4例(8.89%)显著低于对照组的11例(24.4%)(P<0.05)。结论脊柱术后联合应用利伐沙班与血塞通注射液的抗凝效果要好于单一应用利伐沙班抗凝药。

Objective To study the effect of the combination of rivaroxaban and Xuesaitong injection on deep venous thrombosis (DVT) of lower extremity after spinal surgery.Methods The clinical data of 90 patients undergoing spinal surgery from May 2013 to May 2015 were retrospective analyzed.The patients were divided into two groups randomly: the treatment group and control group.Forty-five patients in treatment group were treated with rivaroxaban and Xueshuantong injection from 1 st day after surgery to one week after off-bed activity, and forty-five patients in control group were treated with rivaroxaban alone.The vessels of lower extremity were detected by doppler ultrasonography pre-surgery, 7-10d and 3 months post-surgery, then the rates of DVT and pulmonary embolism were statistically analysed.Results The DVT rate in treatment group was 8.89%(4 cases), which was significantly lower than 24.4% (11 cases) in control group (P<0.05).Conclusion The anticogulant effect of the combination of rivaroxaban and Xuesaitong injection is stronger than rivaroxaban alone.