莫西沙星溶液雾化吸入对慢性阻塞性肺疾病合并呼吸衰竭患者炎症介质及血气分析指标的影响

Effects of moxifloxacin solution for inhalation on inflammatory mediators and blood gas analysis in patients with chronic obstructive pulmonary disease with respiratory failure

目的探讨莫西沙星溶液雾化吸入对慢阻肺合并呼吸衰竭患者炎症介质及血气分析的影响。方法收集嘉善县第一人民医院呼吸科收治的慢阻肺合并呼衰的患者60例,随机分为对照组和实验组,每组各30例,在常规治疗基础上,对照组患者给予吸入用硫酸沙汀胺醇溶液(2 mg/次,每天3次雾化吸入治疗,实验组给予莫西沙星溶液2 mg/次,每天4次雾化吸入治疗,2组患者均治疗2周,对所有患者的血清CRP、TNF-α、IL-10、IL-18水平及动脉血PO2、PCO2水平进行检测。结果与对照组治疗后比较,实验组患者血清CRP、TNF-α、IL-18水平较低(P<0.05),血清IL-10水平较高(P<0.05);实验组患者的动脉血PO2水平较高,PCO2水平较低(P<0.05)。结论莫西沙星溶液雾化吸入能够显著降低慢阻肺合并呼衰患者血清CRP、TNF-α以及IL-18水平,提高血清IL-10水平,改善PO2和PCO2。

Objective To analyse effects of moxifloxacin solution for aerosol inhalation on inflammatory mediators and blood gas analysis index in patients with chronic obstructive pulmonary disease with respiratory failure.Methods 60 patients who were diagnosed with chronic obstructive pulmonary disease with respiratory failure in our hospital were collected.All patients were randomly divided into experimental group and control group,30 cases in each group.On the basis of conventional treatment, control group were given sulfate for inhalation shating amine alcohol solution 2mg per times, 3 times per day atomization inhalation treatment,and experimental group was given 2 mg/times, 4 times per day atomization inhalation treatment,two were treated for 2 weeks.After the treatment, the serum levels of CRP,TNF-α,IL-10,IL-18 and arterial blood PO2 ,PCO2 levels were detected in all patients.Results Compared with control group post-treatment, the serum levels of CRP, IL-18 and TNF-αwere lower in experimental group (P<0.05), and the serum level of IL-10 was higher;the arterial blood level of PO2 was higher,and the arterial blood level of PCO2was lower in experimental group (P<0.05). Conclusion Effect of moxifloxacin solution for aerosol inhalation can significantly reduce the serum CRP,TNF-αand IL-18 levels, improve serum IL-10 level in patients with chronic obstructive pulmonary disease with respiratory failure, ameliorate PO2 and PCO2 .