肢端肥大症144例分析和早期诊断的探讨

ANALYSIS OF 144 CASES OF ACROMEGALY WITH REFERENCE TO ITS EARLY DIAGNOSIS

本文分析144例肢端肥大症的临床表现和实验室资料,旨在探讨本症的早期诊断,尤以放射免疫法测定生长素(GH)空腹值和动态功能试验[葡糖糖GH抑制试验和促甲状腺素释放激素(TRH)兴奋试验]在早期诊断中的意义。

An analysis of clinical manifestations and laboratory findings in 144 cases of acromegaly was made. It showed that the most reliable method for early diagnosis was the measurement of serum growth hormone (GH) level. It was characterized by (1) failure to be suppressed to 5 ng/ml following glucose loading, (2) paradoxical response to thyrotropin-releasing hormone (TRH), an increase of serum GH level greater than 10 ng/ml or a 50％ increase of basal value following iv injection of TRH, and (3) mild abnormality of sella turcica observed through thin layer tomography or CT.