温中解毒汤治疗慢性萎缩性胃炎的疗效观察

Efficacy observation of “Wenzhong Jiedu Decoction”in the treatment of chronic atrophic gastritis

目的:观察温中解毒汤治疗慢性萎缩性胃炎(CAG)的临床疗效。方法:纳入CAG患者82例,随机分为治疗组和对照组,每组各41例。治疗组患者给予温中解毒汤口服治疗,对照组患者给予摩罗丹口服治疗,两组疗程均为6个月。比较两组患者的临床疗效、中医证候积分及病理组织学疗效。结果:治疗后,两组患者的中医证候积分均明显降低(P<0.05),且治疗组患者的积分低于对照组(P<0.05);治疗后,治疗组的临床总有效率为75.61%、对照组为60.98%,两组比较差异有统计学意义(P<0.05),治疗组的疗效优于对照组;治疗后,治疗组的病理组织学疗效总有效率为65.85%、对照组为46.34%,两组比较差异有统计学意义(P<0.05),治疗组的疗效优于对照组。结论:温中解毒汤治疗CAG可有效改善患者的临床症状及病理组织学变化,值得在临床中推广应用。

Objective: To observe the clinical efficacy of"Wenzhong Jiedu Decoction"in the treatment of chronic atrophic gastritis( CAG). Methods: 82 patients with CAG were selected and randomly divided into the treatment group and control group,41 cases in each group. The patients in the treatment group were orally treated with"Wenzhong Jiedu Decoction"and the patients in the control group were orally treated with"Mo Luo Pill",with a course of 6 months. The clinical efficacy,the scores of Chinese medical syndrome and the histopathological efficacy were compared between the two groups. Results: After treatment,the scores of Chinese medical syndrome in both groups were significantly decreased( P<0.05) and the score of the treatment group was lower than that of the control group( P <0.05). After treatment,the clinical total effective rates of the treatment group and the control group were 75. 61% and 60. 98%respectively,with statistically significant difference between the two groups( P<0.05),and the efficacy in the treatment group was better than that in the control group( P<0.05). After treatment,the histopathological total effective rates of the treatment group and the control group were 65.85% and 46.34% respectively,with statistically significant difference between the two groups( P<0.05),and the efficacy in the treatment group was better than that in the control group( P<0.05). Conclusion: "Wenzhong Jiedu Decoction"can improve the clinical symptoms and pathological changes in the treatment of CAG,and is worthy of popularization in clinic.