施杞防治骨代谢疾病的学术思想研究

Shi Qi's academic thoughts of prevention and treatment of bone metabolic diseases

探讨施杞教授防治骨代谢疾病的学术思想。通过临床和基础研究,认为肾精亏虚、阴阳失衡、精亏骨损是骨代谢疾病的病理基础,创立补肾益精和调和肾阴肾阳等治疗法则以及临床系列研究方案、技术和指南;阐明了补肾益精法通过恢复成骨细胞主导的骨生成和破骨细胞主导的骨吸收的平衡,维持骨稳态、防治骨代谢疾病的作用机制。补肾益精法防治骨代谢疾病是对"肾主骨""肾藏精"等理论的发展,进一步拓展了中医药理论在临床实践和基础研究中的指导作用。

This paper discussed Professor Shi Qi's academic thoughts of prevention and treatment of bone metabolic diseases. Through the clinical and fundamental research,he considers the pathological basis of bone metabolic diseases as deficiency of kidney essence,imbalance of yin and yang and bone loss due to essence deficiency,and creates the therapy principle of invigorating kidney for nourishing essence and harmonizing kidney yin and yang,proposes a series of research programs,techniques and guidelines in clinic. He elaborates that the therapy of invigorating kidney for nourishing essence plays a role in the prevention and treatment of bone metabolic diseases through recovering the balance between osteoblast mediated bone formation and osteoclast mediated bone resorption and maintaining bone homeostasis,which are taken as the development of theory of'kidney governing bones''kidney storing essence'and further expand the guiding role of theory of traditional Chinese medicine in clinical practice and fundamental research.