桃红四物汤对胫骨平台骨折固定术后患者骨代谢的影响

Effects of Taohong Siwu Decoction on bone metabolism in patients with fracture of tibial plateau after fixation operation

目的研究桃红四物汤对胫骨平台骨折固定术后患者骨代谢的影响。方法将76例胫骨平台骨折患者随机分为对照组和观察组(各38例),并均行内外双钢板固定治疗;观察组同时加用桃红四物汤治疗,治疗2个疗程。观察两组临床疗效及治疗前后骨代谢指标变化情况。结果观察组临床总有效率为97.37%,对照组为81.59%;观察组的临床疗效优于对照组(P<0.05)。治疗后两组骨形成指标血清ALP、IGF-Ⅰ、PINP和骨代谢指标血清MMP-1、MMP-2、sCTx表达水平均高于治疗前(P<0.05),且观察组均高于对照组(P<0.05)。结论桃红四物汤能够显著改善胫骨平台骨折固定术后患者膝关节功能和骨代谢以促进骨折愈合。

Objective To study the effects of Taohong Siwu Decoction on bone metabolism in patients with fracture of tibial plateau after fixation operation.Methods 76 patients with fracture of tibial plateau were randomly divided into the control group and treatment group,38 cases in each group. All the patients were treated with internal and external double plate fixation. Meanwhile,the patients in the treatment group were treated with Taohong Siwu Decoction in addition,with a course of 28 days. The clinical efficacy was observed in both groups,and the changes of bone metabolism indexes were compared before and after treatment.Results The clinical total effective rate was 97. 37% in the treatment group and 81. 59% in the control group. The clinical efficacy of the treatment group was better than that of the control group( P < 0. 05). Compare with treatment before,the serum levels of bone formation indexes including alkaline phosphatase( ALP),insulin-like growth factor I( IGF-I) and procollagen type I N-terminal propeptide( PINP) and the serum levels of bone metabolism indexes including matrix metalloproteinase-1( MMP-1),matrix metalloproteinase-2( MMP-2) and collagen type I cross-linked C-terminal peptide( sCTx) were increased in both groups after treatment( P < 0. 05),and the levels in the treatment group were all higher than those in the control group( P < 0. 05). Conclusion Taohong Siwu Decoction can significantly improve the knee joint function and bone metabolism in patients with fracture of tibial plateau after fixation operation,which promote the fracture healing.