巨噬细胞极化与动脉粥样硬化相关性及中药干预作用研究进展

Advances in relationship between macrophage polarization and atherosclerosis and intervention effects of traditional Chinese medicine

综述巨噬细胞极化与动脉粥样硬化的相关性及中药干预作用的研究进展。M1型巨噬细胞极化可以促进动脉粥样硬化的发展,而M2型巨噬细胞极化对动脉粥样硬化的发展起到双重作用;丹参、穿心莲、姜黄、肉桂、黄连等中药的提取物,可以通过调节巨噬细胞极化,起到控制动脉粥样硬化进程的作用。

This paper reviews the relationship between macrophage polarization and atherosclerosis and the intervention effects of traditional Chinese medicine. M1 type macrophage polarization can promote the development of atherosclerosis, while M2 type macrophage polarization plays a dual role on atherosclerosis. The extracts of traditional Chinese medicine such as Danshen(Radix SalviaeMiltiorrhizae), Chuɑnxinlian(HerbaAnorographitis), Jianghuang(RhizomaCurcumaeLongae), Guipi(Cortex CinnamomiJaponici), Huɑnglian(RhizomaCoptidis)can control the progression of atherosclerosis by regulating the polarization of macrophages.