佐米曲普坦合成工艺的研究

Study on the Synthetic Technique of Zomitriptan

在合成工艺上以L-苯丙胺酸为起始原料,经7步反应,合成偏头痛治疗新药佐米曲普坦。本实验主要研究由中间体(S)-4-(4-肼基苯甲基)-1,3-口恙唑啶-2-酮和二甲胺基丁缩醛合成佐米曲普坦。此实验路线简单,收率高。操作简便,是目前较佳的制备佐米曲普坦的合成工艺方法。

Zomitriptan which is efficacious for migraine is synthesized by seven steps from L -phenylalanine, and some intermediates are fit for the need of industrial synthesis. In this paper, zomitriptan is synthesized from the intermediates of (s) - 4 - (4 - hydrazinobenzyl) -1, 3-oxazolidin - 2 - one and 4 - chlorobutanal dimethylacetal, the synthesis route is terse, yield is high and operation is simple, at present, it is a good technique of synthesizing zomitriptan.