门静脉营养对肝硬化、门静脉高压的影响

The effects of portal nutrition on liver cirrhosis and portal hypertension

目的 探讨门静脉营养在治疗肝硬化、门脉高压症中的作用。方法 将80例入组患者随机分为两组,对照组40,仅予以常规周围静脉肝营养液输入;研究组40,于术后第1d给予肝营养液门静脉内缓慢输入。两组于术后1、2、4w分别检查血清谷丙转氨酶、胆红素及白蛋白,研究组于术中、术后检测自由门静脉压(FPP)。结果 术后1、2、4w血清谷丙转氨酶、血清胆红素下降速度及血清白蛋白升高速度均较对照组快,4w末肝功复常率两组比较差异存在显著性(P<0.05)。研究组术后早期FPP升高,术后随着肝功恢复及侧支循环的建立,FPP逐渐回落。结论 门静脉营养在肝硬化、门脉高压症治疗中,能短时间内较快恢复肝功。肝营养液门静脉内缓慢输入法具有疗效可靠,操作安全等特点。

Objective To explore the effects of portal nutrition on liver cirrhosis and portal hypertension. Methods Control group (n = 40) only indrop liver nutrient solution in surrounding vein. Test group(n = 40) slow - moving input liver nutrient solution in portal vein after a day of post - operation. Observed consistence of blood bilirubin、ALT and albumin in each groups at 1、2、4 weeks after operation, and freedom portal vein pressure(FPP) in operation and after operation in test group. Results Observed step - up rate of albumin and decline rate of ALT and blood abilirubin each groups at 1、2、4 weeks after operation, and compared the results, it shows the test group have a good performance. Compared live function recovery rates after 4 weeks bettween two groups , the results have significant difference(P < 0.05) . Observed freedom portal vein pressure(FPP) in operation and after operation in test group, it shows FPP increase in early stage after operation and FPP decline slowly as liver function recovered and collateral circulation created. Conclusion Portal nutrition have the virtue of operation safety, effect, reliability and quickly recovery of liver function in a short time at treatment of liver cirrhosis and portal hypertension.