仙鹤草的抗肿瘤作用机制及临床应用综述

Review on Anti-tumor Effects Mechanism and Clinical Application of Agrimonia pilosa

仙鹤草(Agrimonia pilosa)是中国延用两千多年的传统中药材之一,因其具有诸多药理作用而在临床广泛应用于肿瘤等多种疾病。恶性肿瘤是一类严重危害人类健康的疾病,中草药可为综合治疗提供思路。近年来,仙鹤草的抗肿瘤作用得到了医务工作者及科研工作者较多的重视和研究。本文通过实验研究、临床研究和经验总结的文献整理,综述仙鹤草在抗肿瘤方面的作用机制,提示其有诱导肿瘤细胞周期阻滞,诱导肿瘤细胞凋亡,增强对肿瘤细胞免疫的抗肿瘤机制。在临床应用仙鹤草辅助抗肿瘤治疗时,可根据仙鹤草的作用机制及前人经验总结合理使用,充分发挥其扶正、抗肿瘤作用。

Agrimonia pilosa is one of the traditional Chinese herbal medicines for 2000 years history. Due to its various pharmacological effects, it is widely used in the clinical treatment of tumors and other diseases. Presently malignancy has become an important factor threatening human health that the anti-tumor effect of Agrimonia pilosa has attracted great attention. The author reviewed its anti-tumor effect mechanism by articles arrangement of experimental study, clinical study and experience introduction. A series of study revealed 3 mechanisms: blocking cell cycle, inducing apoptosis and strengthening the cellular immunity. As a kind of traditional Chinese herbal medicine which has anti-tumor effect, the Agrimonia pilosa should be reasonably applied according to the related research and previous experience.