摘要
Background: A longer duration treatment is preferred in erythema migrans (EM) to prevent late complaints. Objectives: To determine whether 20 (20d- pt) or 14 days (14d- pt) of phenoxymethylpenicillin (PenV) have similar efficacy in treating EM and preventing further sequelae. Patients and Methods: In a prospective double- centre study, 102 patients with EM were treated with PenV 1.5 million IU thrice daily for either 20 or 14 days and followed up for 12 months. Results: The primary cure rate after treatment with PenV was 91.5% (79.6- 97.6) for 20d- pt vs. 91.7% (77.5- 98.2) for 14d- pt; p >0.99). In 7 patients (420d- pt and 314d- pt), persistent or newly arising symptoms required retreatment. After 1 year, all patients were cured. The immune response showed no statistical difference between the treatment groups in the follow- up period. Conclusion: A 2- week treatment regimen of PenV seems to be as effective as a 3- week course with no statistical differences for clinical and serological findings after treatment.
Background: A longer duration treatment is preferred in erythema migrans (EM) to prevent late complaints. Objectives: To determine whether 20 (20d- pt) or 14 days (14d- pt) of phenoxymethylpenicillin (PenV) have similar efficacy in treating EM and preventing further sequelae. Patients and Methods: In a prospective double- centre study, 102 patients with EM were treated with PenV 1.5 million IU thrice daily for either 20 or 14 days and followed up for 12 months. Results: The primary cure rate after treatment with PenV was 91.5% (79.6- 97.6) for 20d- pt vs. 91.7% (77.5- 98.2) for 14d- pt; p >0.99). In 7 patients (420d- pt and 314d- pt), persistent or newly arising symptoms required retreatment. After 1 year, all patients were cured. The immune response showed no statistical difference between the treatment groups in the follow- up period. Conclusion: A 2- week treatment regimen of PenV seems to be as effective as a 3- week course with no statistical differences for clinical and serological findings after treatment.
