摘要
Objective: We analyzed postnatal growth in children with familial short stature (FSS)with regard to small (SGA) or appropriate(AGA) for gestational age status at birth. Study design: We studied 96 otherwise healthy short-statured children (58 males;SGA: n = 41, AGA: n = 55). At least one of the parents was short-statured. Cross-sectional data for length/height and weight for the first 4 years of age were collected retrospectively.Results: AGA children had a mean length of 0.09 ±1.02 standard deviation score (SDS) at birth, -1.57 ±1.16 SDS after 1year of age, and -2.36 ±0.72 SDS after 4 years. SGA children had a mean length of -2.04 ±1.06 SDS at birth, -2.70 ±1.12 SDS at 1 year of age, and -3.05±0.86 SDS at 4 years. The loss of length SDS within the first 2 years of life was greater in AGA than in SGA children. SGA children were significantly shorter than AGA children at all of the study points (p < 0.001). Conclusions:Children with an FSS background born AGA show catch-down growth to their lower familial range during the first 2 years of life. SGA children did not catch up to their AGA peers at any time.
Objective: We analyzed postnatal growth in children with familial short stature (FSS)with regard to small (SGA) or appropriate(AGA) for gestational age status at birth. Study design: We studied 96 otherwise healthy short-statured children (58 males;SGA: n = 41, AGA: n = 55). At least one of the parents was short-statured. Cross-sectional data for length/height and weight for the first 4 years of age were collected retrospectively.Results: AGA children had a mean length of 0.09 ±1.02 standard deviation score (SDS) at birth, -1.57 ±1.16 SDS after 1year of age, and -2.36 ±0.72 SDS after 4 years. SGA children had a mean length of -2.04 ±1.06 SDS at birth, -2.70 ±1.12 SDS at 1 year of age, and -3.05±0.86 SDS at 4 years. The loss of length SDS within the first 2 years of life was greater in AGA than in SGA children. SGA children were significantly shorter than AGA children at all of the study points (p < 0.001). Conclusions:Children with an FSS background born AGA show catch-down growth to their lower familial range during the first 2 years of life. SGA children did not catch up to their AGA peers at any time.
