便通胶囊对比麻仁胶囊防治抗精神分裂症药物所致便秘的临床观察

Clinical Observation on Preventive and Therapeutic Effects Comparative of Biantong Capsule and Maren Capsule on Patients with Constipation Induced by Antipsychotic

目的:比较便通胶囊和麻仁胶囊防治抗精神分裂症药物所致便秘的临床疗效,为临床防治精神分裂症药物所致便秘提供参考依据。方法:选取2016年1月至2017年12月河南省精神病医院收治的精神分裂症患者120例作为研究对象,按照随机数字表法分为观察组和对照组,每组60例。对照组患者给予麻仁胶囊治疗,观察组患者给予便通胶囊治疗。2组患者均以2周为1个疗程,疗程间休息2周,治疗和随访持续1年。观察2组患者便秘无效率、便秘发生率、平均便秘次数和不良反应。结果:观察组便秘无效率、便秘发生率低于对照组,平均便秘次数少于对照组,差异均有统计学意义(均P <0. 05),同时观察组的不良反应率更低(P <0. 05)。结论:便通胶囊防治抗精神分裂症药物所致便秘的临床疗效优于麻仁胶囊,且不良反应低,是防治抗精神分裂症药物所致便秘有效且安全药物,值得临床推广使用。

Objective: To compare the clinical preventive and therapeutic effect S of Biantong capsule and Maren capsule on patients with constipation induced by antipsychotic,and provide a basis to treat patients with constipation induced by antipsychotic.Methods: A total of 120 schizophrenic patients admitted to Henan Psychiatric Hospital from January 2016 to December 2017 were selected. The patients were randomly divided into the control group and the observation group,with 60 cases in each group. The patients in the observation group were given Biantong capsules while patients in the control group were given Maren capsules. Two weeks as a course of treatment,there were two weeks in the treatment between the rest,treatment and follow-up for a year. The constipation inefficient,the incidence of constipation,average constipation frequency and adverse reactions of the 2 groups were observed. Results: The constipation inefficient,the incidence of constipation and average constipation frequency in the observation group were lower than that of the control group,and the difference was statistically significant( P < 0. 05). The adverse reaction rate of the observation group was lower( P < 0. 05). Conclusion: There has good effects of the Biantong capsule to treat constipation induced by antipsychotic,which was better than Maren capsules and the adverse reactions was lower. It is a safe and effective drug to treat constipation induced by antipsychotic and worth wide use in the clinical practice.