乳腺癌患者中医体质类型、证候分布及其相关性研究

Research on the Relationship Between the Body Constitution Type in TCM and Clinical Syndromes of the Breast Cancer

目的:中医体质的角度探讨乳腺癌的高危因素,为乳腺癌的预防和早期治疗提供新思路、新途径。方法:选取2014年10月至2016年12月在深圳大学医学院第一附属医院门诊及住院部的乳腺癌患者504例(观察组)及同期进行健康体检的正常女性504例(对照组)为研究对象。应用大样本描述性流行病学的横断面调查研究和非配对的病例对照研究。纳入采用问卷调查法统计研究对象的一般资料、中医体质类型、证候分布等,比较2组基础资料、中医体质类型,总结出乳腺癌患者中医体质和中医证型之间的相关性,分析其与乳腺癌患者生存时间关系。结果:乳腺癌患者中医体质分型从高到低前3位依次为:阴虚质102例(20. 24%),气郁质98例(19. 44%),痰湿质72例(14. 29%)。不同中医体质类型乳腺癌患者生存时间差异有统计学意义(χ2=32. 044,P=0. 000),其中阴虚质生存时间最短,其次是气郁质;不同中医证候分布型乳腺癌患者生存时间差异有统计学意义(χ2=34. 506,P=0. 000),其中阴虚型生存时间最短,其次是肝气郁结型。结论:乳腺癌患者以气郁质、阴虚质2种体质多,长期肝郁不畅导致胸胁脉络气机不利,与乳腺癌发生密切相关。

Objective: To explore the high risk factors of breast cancer from the perspective of Traditional Chinese Medicine( TCM) Constitution,and to provide new ideas and approaches for the prevention and early treatment of breast cancer. Methods: A large sample descriptive epidemiological cross-sectional study and a non-matched case-control study were conducted. From October2014 to December 2016,a total of 504 cases of breast cancer patients( case group) at the First Affiliated Hospital of the First Affiliated Hospital of Shenzhen University and 504 healthy women( control group) at the same time were studied. The general data of the subjects,the type of TCM constitution and the distribution of syndromes were analyzed by questionnaire survey The basic data of the 2 groups and the types of TCM Constitution were compared,and the correlation between the constitution of Chinese medicine and the TCM syndrome type of the patients with breast cancer was summarized,and the relationship with the survival time of the patients with breast cancer was analyzed. Results: There were 102 cases of yin-deficiency constitution( 20. 24%),98 cases of qi-depression constitution( 19. 44%),72 cases of phlegm-wet constitution( 14. 29%),from high to low in the first three cases. The survival time of breast cancer patients with different Chinese physique types was different( χ2= 32. 044,P = 0. 000),among which the survival time of yin-deficiency constitution was the shortest and the second was qi-depression constitution. Conclusion: The patients with breast cancer mostly have either of these 2 kinds of constitution,qi-depression or yin-deficiency,which suggest that chronic stagnation of the liver is unfavorable to the chest and choroid machine,and it is closely related to the occurrence of breast cancer.