Wnt/β-catenin信号通路在类风湿关节炎中的表达

Expression of Wnt/β-catenin Signaling Pathway in Knee Joint of Type II Collagen-induced Arthritis Model Rats

类风湿关节炎(Rheumatoid Arthritis,RA)是以滑膜炎为主要病理表现的系统性疾病,目前已有研究证实,Wnt/β-catenin信号通路是类风湿关节炎发生发展的关键环节。一方面Wnt/β-catenin信号通路活化促进成骨细胞增殖分化,促进骨组织修复;另一方面,成纤维样滑膜细胞中Wnt/β-caten in通路上调,促进成纤维样滑膜细胞增殖,加重软组织增生,破坏骨关节。因此如何通过调节Wnt/β-catenin通路抑制成纤维样滑膜细胞增殖的同时促进骨修复对RA治疗具有重要研究意义。

Rheumatoid arthritis( RA) is a systematic disease characterized by synovitis. It has been confirmed that Wnt/β-catenin signaling pathway plays a key role in the development of rheumatoid arthritis. On one hand,Wnt/β-catenin signaling pathway promotes the proliferation and differentiation of osteoblasts,on the other hand,the up-regulated Wnt/β-catenin signaling pathway in fibroblast like synovial cells can lead to fibroid synovial cells proliferation,proliferation of RA soft tissue and bone damage. Therefore,how to restrain the proliferation of fibroid synovial cells to inhibit the proliferation of synovium,and promote bone repair thought Wnt/β-catenin signaling pathway is of great significance to RA treatment.