中药剂型理论的现代药物动力学诠释

Modern Pharmacokinetic Interpretation of the Theory of Chinese Medicaments

中医很早就开始探讨剂型与疗效之间的关系,《神农本草经》发现了服药方法对于疗效的影响,汉代张仲景第一次系统论述了汤、散、丸对疗效的影响,沈括、李东垣进一步论述了剂型理论。中医对人体的认识与现代药物动力学的经典房室理论观念相符,中药剂型理论包含了现代药物动力学最基本的观点,能够被药物动力学理论所诠释。

The relationship between Chinese medicaments and efficacies has been early explored in TCM. Shennong Bencao Jing discovered the impacts of medical usage on the efficacy. Zhang Zhongjing of the Han dynasty is the first person to state the impacts of decoction,powder and pill on the efficacy. Shen Kuo and Li Dongyuan further stated the medicament theory. The theoretical concepts of TCM on human body are consistent with modern classical compartment model of pharmacokinetic. The theory of medicaments implies the basic pharmacokinetic viewpoint,and can be interpreted by the pharmacokinetic theory.