火针治疗结节性痒疹48例临床观察

Clinical Observation of Fire Needle in the Treatment of Patients with Nodular Prurigo

目的观察火针治疗结节性痒疹的临床疗效及安全性。方法结节性痒疹患者98例,随机分2组,治疗组48例,采用火针治疗;对照组50例,采用液氮冷冻治疗。两组连续治疗4周,所有病例8周后比较有效率并观察不良反应,随访半年观察疾病复发情况。结果治疗组总有效率73.91%,对照组总有效率46.94%,差异有统计学意义(P<0.01)。治疗组和对照组分别发生5例和27例不良反应事件。随访半年后发现,治疗组8例痊愈者中有2例复发,对照组5例痊愈者中有3例复发。结论火针治疗结节性痒疹有较好的临床疗效及安全性。

Objective To observe the clinical effect and safety of fire needle in the treatment of patients with nodular prurigo. Methods A total of 98 patients with prurigo nodularis,were randomly divided into 2 groups. The 48 cases in the experimental group were given fire needle therapy. Another 50 cases in the control group received liquid nitrogen cryotherapy. Two groups both applied continuous treatment for 4 weeks,and the efficiency and the adverse reactions of all the patients after 8 weeks were observed and compared. The relapse rates of the two groups were also observed after 6- month follow- up. Results The total effective rate in the fire needle group was 73. 91%,which was significantly higher than that in the control group( 46. 94%,P < 0. 01). There were respectively 27 and 5 cases of mild adverse events in the control and fire needle groups. During the 6- month follow- up,the relapse rates were 60%( 3 /5) and 25%( 2 /8) among the completely effective patients in the control and fire needle groups,respectively. Conclusion Compared with the conventional medicine,fire needle could be an alternative for the treatment of nodular prurigo with better clinical effect and safety.