茵栀黄口服液联合丹参治疗孕期母儿血型不合45例

Yinzhihuang Oral Solution Combined with Salval in Treating Maternal-fetal ABO Blood Group Incompatibility

目的探讨茵栀黄口服液联合静脉滴注丹参注射液治疗孕期母儿血型不合的临床效果。方法选择孕期抗体效价>1∶64并正常分娩的孕妇135例,随机分为西药组、中药组、中药+丹参组,每组45例。西药组常规给予25%葡萄糖+维生素C缓慢静推,鼻导管吸氧治疗;中药组口服茵栀黄口服液;中药+丹参组口服茵栀黄口服液,同时静脉滴注丹参注射液。观察孕妇不同抗体效价的治疗效果及新生儿黄疸的发生情况。结果当抗体效价<1∶256时,中药组及中药加丹参组有效率均高于西药组,而中药组与中药加丹参组有效率比较,差异无统计学意义(P>0.05)。当抗体效价>1∶256时,中药组及中药加丹参组有效率均高于西药组,且中药加丹参组有效率高于中药组,差异有统计学意义(P<0.05)。中药组及中药加丹参组新生儿黄疸发生率低于西药组,差异有统计学意义(P<0.05)。结论茵栀黄口服液联合丹参注射液治疗孕期母儿血型不合可显著提高治疗效果,并且可使新生儿黄疸的发生率进一步降低,值得临床推广。

Objective To analyze the clinical effect of Yinzhihuang Oral Solution combined with Salval in the treatment of maternal - fetal ABO blood group incompatibility. Methods A total of 145 cases of the maternal - fetal ABO blood group incompatibility whose antibody titer ≥1: 64 were included. Were ran-domly divided the patients into three groups:the 45 cases of these were treated with intravenous infusion of glucose and vitamin C. The 45 cases of these were administered with Yinzhihuang Oral Solution. While the rest 45 were treated with Yinzhihuang Oral Solution combined with Salval. A treatment course was 4 weeks. The variation of antibody titer of the pregnancy and the incidence of neonatal jaundice were observed. Results When the antibody titer was < 1: 256,the effect of Yinzhihuang Oral Solution and Salval group were higher than that of the western medicine group. There was no difference between Yinzhihuang Oral Solution and Salviae group(P > 0. 05). Moreover,when the antibody titer was > 1: 256,the effect of Yinzhihuang Oral So-lution was higher than that of the Salval group(P < 0. 05). The neonatal jaundice incidence of Yinzhihuang Oral Solution and Salval group was significantly better than that of the non - treatment group(P < 0. 05). Conclusion Yinzhihuang Oral Solution and Salval Significantly can improve the therapeutic effect and be-come much lower in neonatal jaundice incidence.