中药联合肝动脉灌注栓塞治疗肝癌的临床研究

Clinical Research of Liver Cancer Treated with Chinese Medicine and Transarterial Chemoembolization

目的探讨中药联合肝动脉介入化疗栓塞(TACE)治疗肝癌的临床效果。方法将2008年1月至2011年2月收治的原发性肝癌患者随机分为观察组(78例)和对照组(80例),两组均给予肝动脉灌注栓塞治疗,观察组另加自拟中药组方煎汤口服。1个疗程后观察两组的临床疗效,生存率,生化指标[丙氨酸氨基转移酶(ALT)、甲胎蛋白(AFP)],生活质量,不良反应情况。结果观察组总有效率为85.90%,明显高于对照组(67.50%),两组比较差异有统计学意义(P<0.05)。观察组1、3年生存率,ALT、AFP、生活质量改善情况明显优于对照组(P<0.05),且不良反应较对照组也明显降低(P<0.05)。结论 TACE联合中药治疗肝癌效果显著,毒副作用小,值得临床推广。

Objective To discuss the clinical effects on liver cancer treatment with Chinese medi-cine and transarterial chemoembolization(TACE). Methods The patients of primary liver cancer,treated from January 2008 to February 2011 were randomized into an observation group(78 cases)and a control group(80 cases). TACE was applied in both of the two groups. In the observation group,the self - prepared herbal decoction was added for oral administration. After 1 session of treatment,the clinical efficacy,survival rate,biochemical indicators( ALT,AFP),living quality and adverse reactions were observed in the two groups. Results In the observation group,the total effective rate was 85. 90% ,higher apparently than 67. 50% in the control group,indicating the significant difference(P < 0. 05). In the observation group,the improvements in the 1 and 3 year survival rate,ALT,AFP and living quality were apparently better than those in the control group(P < 0. 05);and the adverse reaction was reduced apparently as compared with the con-trol group(P < 0. 05). Conclusion The combined therapy of TACE and Chinese medicine achieves the sig-nificant effect on liver cancer. It has less toxic side effect and deserves to be promoted in clinical practice.