天麻藤玉丸治疗高血压早期肾损害阴虚阳亢证临床研究

Clinical Research of Tianma Tengyu Pills in the Treatment of Early Renal Damage in Hypertension Differentiated as Yin Deficiency and Yang Hyperactivity

目的观察天麻藤玉丸治疗高血压早期肾损害的临床疗效,拟进一步验证其降压及逆转高血压所致肾损害的作用。方法将120例符合标准的高血压早期肾损害患者随机分为天麻藤玉丸合贝那普利治疗的治疗组与单用贝那普利治疗的对照组,各60例。所有患者均接受1周洗脱期治疗。洗脱期结束后,进入临床研究阶段。对照组予以盐酸贝那普利片10 mg口服,1次/d。治疗组在对照组治疗的基础上,加用天麻藤玉丸9 g/次,2次/d。两组均以12周为1个疗程。观察比较治疗12周前后的血压、血胱抑素C、血β2-微球蛋白的变化。结果研究显示,治疗组比对照组能更好地降低血压变异性(P<0.05),显著降低血胱抑素C及血β2-微球蛋白(P<0.05),两组均未见严重不良反应发生。结论天麻藤玉丸能降低血压变异性和改善肾功能,减轻或延缓高血压患者早期肾损害的发展。

Objective To observe the clinical efficacy of tianma tengyu pills in the treatment of early renal damage in hypertension and intend to verify its effects of anti-hypertension and reversion of renal damage induced by hypertension. Methods One hundred and twenty patients of early renal damage of hypertension were randomized in a treatment group and a control group,60 cases in each one. All of patients received washout period for 1 week before entering clinical research phase. In the control group,benazepril hydrochloride tablets were taken orally,10 mg,once a day. In the treatment group,on the basis of the treatment as the control group,tianma tengyu pills were added,9g each time,twice a day. In the two groups,the treatment for 12 weeks was as one session. The blood pressure,Cys C and β2-MG were observed and compared before and after treatment in 12 weeks. Results The research results showed that the variability of blood pressure in the treatment group was reduced better as compared with the control group( P < 0. 05). Cys C andβ2-MG were reduced significantly in the treatment group as compared with those in the control group( P <0. 05). The severe adverse reaction was not discovered in the two groups. Conclusion Tianma tengyu pills reduce the variability of blood pressure,improve renal function and retard the development of early renal damage induced by hypertension in the patients.