丹参酮注射液治疗冠心病心绞痛74例临床观察

Clinical Observation of Tanshinone Injection in the Treatment of 74 Cases of Coronary Angina Pectoris

目的探讨应用丹参酮注射液对冠心病心绞痛患者临床疗效及血清同型半胱氨酸水平的影响。方法选取我院于2012年3月-2014年12月期间收治的74例冠心病心绞痛患者作为研究对象,并按照随机数字表法将其分为对照组和治疗组,每组37例。两组患者都采用常规的西医疗法,对于伴发高血脂、糖尿病以及高血压的患者同时给予相应降脂、降糖和降压的药物治疗,而治疗组患者在常规西医治疗方案的基础上加用丹参酮注射液,2周为1个疗程。治疗后,观察并比较两组患者的临床总体疗效及治疗前后两组患者同型半胱氨酸水平、心电图、心绞痛改善情况的变化。结果治疗后,治疗组和对照组患者临床疗效的总有效率分别为91.89%和70.27%,中医证候疗效的总有效率分别为94.59%和72.97%,差异有统计学意义(P<0.05)。治疗后,治疗组和对照组患者同型半胱氨酸的水平分别为(9.82±2.75)、(13.92±3.87)μmol/L,治疗组患者同型半胱氨酸的水平相对治疗前显著降低(P<0.05),且治疗后与对照组比较,差异有统计学意义(P<0.05),而对照组患者该指标的水平虽有下降的趋势,但不明显,与治疗前比较,差异无统计学意义(P>0.05)。治疗后,治疗组和对照组患者心电图改善的总有效率分别为81.08%和59.45%,组间比较差异有统计学意义(P<0.05);治疗组和对照组患者心绞痛改善情况的总有效率分别为94.59%和70.27%,差异有统计学意义(P<0.05)。结论丹参酮注射液联合常规西医疗法相对常规西医疗法治疗冠心病心绞痛的效果更好,能够明显改善患者心绞痛和心电图的状况,且可有效降低患者同型半胱氨酸水平。

Objective To observe the impacts of tanshinone injection on the clinical efficacy and serum homocysteine level in the patients of coronary angina pectoris. Methods From March 2012 to December 2014,74 cases of angina pectoris were selected as the subjects and were divided into a control group and a treatment group,37 cases in each one according to the random number table. The routine western medicine was used in the patients of the two groups. The drugs for reducing blood lipid,blood glucose and blood pressure were prescribed accordingly for the complications as hyperlipidemia,diabetes and hypertension. In the treatment group,on the basis of the treatment of routine western medicine,tanshinone injection was added.The treatment for 2 weeks as 1 session. After treatment,the clinical overall efficacy,homocysteine level,ECG and the improvement in angina pectoris were observed and compared before and after treatment. Results After treatment,the total effective rates for the clinical efficacy were 91. 89% and 70. 27% in the treatment group and the control group respectively. The total effective rates for TCM syndrome were 94. 59% and72. 97%,indicating the significant difference( P < 0. 05). After treatment,the levels of homocysteine were( 9. 82 ± 2. 75) μmol/L and( 13. 92 ± 3. 87) μmol/L in the treatment group and the control group respectively. The level in the treatment group after treatment was reduced significantly as compared that before treatment( P < 0. 05). The differences after treatment were significant as compared with the control group( P <0. 05). The level in the control group was reduced in tendency,but not apparent and without significant difference as compared with that before treatment( P > 0. 05). The total effective rates for ECG improvementwere 81. 08% and 59. 45% in the treatment group and the control group after treatment,indicating the significant difference in comparison( P < 0. 05). The total effective rates for the improvements in angina pectoris were 94. 59% and 70. 27% in the two groups respectively,indicating the significant differences( P < 0. 05).Conclusion The combination of tanshinone injection and routine western medicine achieves the better effect on angina pectoris as compared with simple western medicine. It apparently relieves angina pectoris and improves ECG conditions,as well as effectively reduces homocysteine level.