口服中药联合西药治疗甲状腺癌术后临床疗效的Meta分析

Meta-analysis on the effects on thyroid cancer after operation in the treatment with co-medication of Chinese herbal medicine and western medicine

目的系统评价口服中药联合西药治疗甲状腺癌术后的临床疗效。方法计算机检索中国知网(CNKI)、维普中文数据库(VIP)、万方数据库、Pub Med数据库等中英文数据库,并使用Rev Man5. 3软件进行Meta分析。结果共纳入10篇中文文献,Meta分析结果显示:口服中药联合西药治疗甲状腺癌术后在降低TSH(P=0. 006)、降低TG(P <0. 000 1)和提高卡氏评分(P=0. 000 1)方面均优于西药对照组,差异有统计学意义;其改善卡氏评分疗效(P <0. 000 1)和临床证候疗效(P <0. 000 01)方面亦优于西药对照组,差异有统计学意义。结论口服中药联合西药治疗甲状腺癌术后的临床疗效优于单纯西药治疗,且能够降低TSH和TG水平、提高卡氏评分、改善症状、减少不良反应的发生。

Objective To evaluate systematically the clinical effects of co-medication of Chinese herbal medicine and western medicine on thyroid cancer after operation.Methods The related articles of both Chinese and English on RCTs were retrieved from CNKI,VIP,Wanfang and Pub Med databases.Rev Man 5.3 software was used for meta-analysis.Results A total of 10 eligible articles were collected.Meta-analysis showed that after co-medication of Chinese herbal medicine and western medicine,the decrease of TSH(P=0.006)and TG(P<0.001)and increase of Karnofsky score(P=0.000 1)were better than simple medication of western medicine in treatment of thyroid cancer after operation,indicating the significant differences.The improvements in Karnofsky score(P<0.000 1)and clinical effects on symptoms(P<0.000 1)in the combined medication group were better than western medicine group,indicating the significant differences.Conclusion The co-medication of Chinese herbal medicine and western medicine achieves the better clinical effects on thyroid cancer after operation as compared with simple use of western medicine.It reduces TSH and TG,improves Karnofsky score and reduces adverse reactions.