长效托宁应用于急性有机磷农药中毒患者中的效果研究

Effect of Long-acting Toning on Acute Organophosphorus Pesticide Poisoning

目的:探讨长效托宁应用于急性有机磷农药中毒患者中的效果。方法:选择2008年1月～2011年12月某院收治的急性有机磷农药中毒患者100例,以随机数表法将其分为对照组(采用阿托品治疗)与研究组(采用长效托宁治疗)各50例,对比两组患者抢救成功率、死亡率、症状消失时间、用药次数及药物不良反应。结果:研究组抢救成功率为96.0%,高于对照组88.0%(P<0.05);研究组死亡率为4.0%,低于对照组12.0%(P<0.05);研究组临床症状消失时间与用药次数均低于对照组(P<0.05);研究组视力模糊、心律失常、尿潴留的发生率均低于对照组(P<0.01)。结论:长效托宁应用于急性有机磷农药中毒患者中的效果满意,值得推广。

Objective:To investigate the effect of long-acting toning on acute organophosphorus pesticide poisoning. Methods: 100 cases of acute organophosphorus pesticide poisoning in a hospital from January 2008 to December 2011 were selected and divided into the control group(atropine treatment) and the study group(long-acting toning treatment),50 cases in each group. The rescue success rate, mortality rate, symptom disappearance time, medication frequency and adverse drug reactions were compared between the two groups. Results: The success rate of rescue in the study group was 96.0%, higher than 88.0% in the control group(P<0.05). Mortality was 4.0% in the study group, lower than 12.0% in the control group(P<0.05). The time of clinical symptoms disappearing and the frequency of drug administration in the study group were lower than those in the control group(P<0.05). The incidence of blurred vision, arrhythmia and urinary retention in the study group was lower than that in the control group(P<0.01). Conclusion: The effect of long-acting toning on patients with acute organophosphorus pesticide poisoning is satisfactory and is worth popularizing.