SOCS-3在肝纤维化中的作用及中药干预的研究进展

The role of SOCS-3 in liver fibrosis and research progress in the intervention of traditional Chinese medicine

慢性肝病是全世界发病率及死亡率最高的疾病之一。肝纤维化是各种慢性肝病进展为肝硬化的必经阶段。大量研究证实,肝纤维化的病理过程可以逆转,但目前尚未被攻克,因此,寻找有效治疗肝纤维化的方法十分必要。近些年来研究表明,SOCS-3在肝纤维化不同阶段扮演不同角色,其可通过影响细胞增殖、细胞周期、细胞因子及信号转导等干预肝纤维化,可能成为治疗肝纤维化的潜在靶标。同时,很多中药可通过影响SOCS-3来发挥改善肝纤维化的作用。本文就SOCS-3在肝纤维化中的作用及中药干预的研究进行分析综述,为进一步研究治疗肝纤维化的有效方法提供参考。

Chronic liver disease is one of the diseases with the highest morbidity and mortality in the world.Liver fibrosis is a necessary stage for various chronic liver diseases to progress to cirrhosis.A large number of studies have proved that the course of liver fibers can be reversed.However,there is no particularly effective treatment of liver fibrosis in the clinic currently,so it is necessary to find effective treatment for liver fibrosis.In recent years,studies have shown that SOCS-3 plays different roles in different stages of liver fibrosis,which can interfere with liver fibrosis by affecting inflammatory response,cell proliferation,cytokines and signaling,and SOCS-3 may become potential targets for the treatment of liver fibrosis.Studies have found that many Chinese medicines can play a role in improving liver fibrosis by affecting SOCS-3.This article reviewed the role of SOCS-3 and the study of traditional Chinese medicine intervention in liver fibrosis,and provided a reference for further research on effective treatment of liver fibrosis.