Kupffer细胞在非酒精性脂肪肝病中的作用

The role of Kupffer cells in nonalcoholic fatty liver disease

非酒精性脂肪性肝病(non-alcoholic fatty liver disease, NAFLD)是一种无过量饮酒史、以肝细胞脂肪变性和脂肪贮积为特征的临床病理综合征。Kupffer细胞是位于肝脏中的特殊巨噬细胞,是先天免疫中的重要组成部分,在肝脏疾病中起关键作用。多项研究表明,Kupffer细胞在NAFLD的发生发展过程中起重要作用。本文总结了Kuffer细胞在NAFLD疾病发生发展中的多重作用,旨在为NAFLD的治疗提供一个有效的靶点。

Non-alcoholic fatty liver disease(NAFLD)is a clinical pathological syndrome characterized by no history of excessive drinking,hepatic steatosis and fat accumulation.Kupffer cells,special macrophages located in the liver,are an important component of innate immunity and play a key role in liver disease.In recent years,several studies have shown that Kupffer cells play an important role in the development of NAFLD.This review summarizes the multiple roles of Kuffer cells in the development of NAFLD,aiming to provide an effective target for the treatment of NAFLD.