转录因子Sp1在心血管疾病中的作用

The role of transcription factor Sp1 on cardiovascular diseases

特异性蛋白1(specificity protein 1, Sp1)是Sp/KLF转录因子家族中最先被发现的一个转录因子。Sp1通过与靶基因启动子上特定的识别位点相结合,从而调控基因的表达,发挥调节细胞生理功能的作用。同时,Sp1的表达和功能也受到乙酰化、磷酸化、泛素化等翻译后修饰的影响。Sp1参与调节心肌细胞凋亡、心肌肥大、心肌纤维化、心肌细胞炎性反应、氧化应激和血管内皮细胞损伤、脂质沉积等多种病理过程,进而影响冠心病、心肌病和动脉粥样硬化等疾病的发生发展。本文将对Sp1在心血管疾病中的研究进展作一综述,以期为心血管疾病的防治提供新视野。

As a transcription factor,specificity protein 1(Sp1)was the first one to be discovered in the Sp/KLF transcription factors family.Sp1 regulates gene expression by binding to specific recognition sites on target gene promoters,and plays a role in regulating cell biological functions,meanwhile,the expression and function of Sp1 are also affected by post-translation modifications such as acetylation,phosphorylation and ubiquitination.In recent years,it has been found that Sp1 is involved in the regulation of myocardial apoptosis,myocardial hypertrophy,myocardial fibrosis,myocardial inflammatory response,oxidative stress,vascular endothelial cell injury,lipid deposition and other pathological processes,and thereby affecting the occurrence and development of coronary heart disease,cardiomyopathy,atherosclerosis and so on.This article will review the research progress of Sp1 in cardiovascular diseases in order to provide a new vision for the prevention and treatment of cardiovascular diseases.