摘要
长链非编码RNA(long non-coding RNA, lncRNA)参与基因表达的调控,在白血病的发生和发展过程中可通过多种机制调控细胞增殖、凋亡等过程,发挥促癌或抑癌作用。本文对lncRNA ZEB1-AS1、lncRNA NALT、lncRNA H19、lncRNA PLIN2、lncRNA MEG3、lncRNA CASC15、lincRNA-p21等lncRNA分别在白血病中的生物学功能及其调控细胞增殖和凋亡的机制进行了简要概述,旨在为白血病的诊疗和预后提供新策略。
Long non-coding RNA(lncRNA)involves in the regulation of gene expression.During the occurrence and development of leukemia,lncRNAs have been implicated in cell proliferation and apoptosis,which plays a role of enhancing or suppressing cancer growth.We discuss the biological functions of lncRNAs ZEB1-AS1,lncRNA NALT,lncRNA H19,lncRNA PLIN2,lncRNA MEG3,lncRNA CASC15 and lincRNA-p21 in leukemia and their regulation on cell proliferation and cell apoptosis in this review,aiming to provide new strategys for the diagnosis,treatment and prognosis of leukemia.
作者
刘美
童晨曦
姜晓玲
宋银宏
LIU Mei;TONG Chenxi;JIANG Xiaoling;SONG Yinhong(Department of Pathogen and Immunology,College of Medical Science,China Three Gorges University,Institute of Infection and Inflammation,China Three Gorges University,Yichang 443002,China)
出处
《生命的化学》
CAS
CSCD
2019年第3期504-509,共6页
Chemistry of Life
基金
国家自然科学基金项目(81671397)
关键词
长链非编码RNA
白血病
增殖
凋亡
long non-coding RNA
leukemia
proliferation
apoptosis
