多发性硬化中适应性免疫细胞的致病机制

The role of adaptive immune cells in multiple sclerosis

多发性硬化(multiple sclerosis, MS)是发生于中枢神经系统(central nervous system, CNS)的慢性进行性免疫炎性疾病,伴随少突胶质细胞、神经元和轴索的破坏。近年来研究发现,外周淋巴细胞(包括T细胞、B细胞及其亚群)在中枢神经系统的浸润作为MS的早期标志之一,在其发病和发展中起到重要作用,但其中许多细胞亚群的具体作用机制尚不明确。该综述通过总结最新研究结果,探讨外周适应性免疫细胞与中枢神经系统炎症关系以及不同种类适应性免疫细胞在MS中行使的功能。

Multiple sclerosis(MS) is a chronic progressive inflammatory disease with highly heterogeneous, chronic inflammatory and demyelinating perivascular lesions within the central nervous system(CNS). Recent studies have found that as one of the early signs of MS, the infiltration of the peripheral lymphocytes(including T cells, B cells and their subsets) in CNS plays an important role in the initiation and development of the disease. However, the specific function of these cells remains unclear. Here we give an overview on how peripheral adaptive immune cells present in CNS inflammation and summarize the latest researches of MS pathogenesis in order to understand how adaptive immune cells may contribute to the disease.