非编码RNA与肺纤维化的相关研究进展

Research progress of non-coding RNA in pulmonary fibrosis

肺纤维化(pulmonary fibrosis, PF)是一种慢性进行性的肺间质损伤性疾病,其发病机制复杂,确诊后中位生存期短,目前缺乏确切有效的治疗方法。因此,明确PF的发病机制对于寻找有效的治疗靶点十分重要。非编码RNA (noncoding RNA, ncRNA)是从基因组中转录而来,不编码蛋白质的RNA。近几年来,研究者们发现,ncRNA在机体多种生物学过程中发挥了重要调控作用,并对其日益重视。已有许多研究表明,ncRNA在PF的发生发展中具有重要作用。现就近年来关于ncRNA在PF中的研究进展以及未来通过干预相关ncRNA来治疗PF的前景及挑战作一综述。

Pulmonary fibrosis(PF) is a chronic and progressive pulmonary interstitial injury disease. The median survival time after diagnosis is short. Its pathogenesis is complex. At present, there is no definite and effective treatment. Therefore, it is very important to clarify the pathogenesis of PF for finding effective therapeutic targets.Noncoding RNA(ncRNA) is transcribed from the genome, but does not encode protein. In recent years, researchers have discovered that ncRNAs play an important role in regulating a variety of biological processes and attach more importance to them. Many studies have shown that ncRNA plays an important role in the development of PF. This article reviews the recent researches on ncRNA in PF and the future prospects and challenges of treating PF by intervening with related ncRNAs.