雌激素对鸣禽中枢神经系统的调控作用

The role of estrogens in the regulation of the central nervous system in songbirds

鸣禽是研究人类语言学习与产生的重要模式动物。鸣禽鸣唱需要感知和运动技能学习等神经过程的参与。鸣禽脑内的雌激素主要是雌二醇(estradiol, E2),由脑内睾酮(testosterone, T)通过芳香化酶的作用转化而来。目前已在雌激素对鸣禽中枢神经系统的调控作用方面获得了一系列重要成果,主要集中在雌激素对鸣禽听觉编码、脑损伤修复,以及空间记忆和鸣唱行为的调控作用。该文对雌激素调控鸣禽中枢神经系统进展进行论述。

Songbirds are important model animals for studying human language learning and production.Neural processes such as perception and motor skill learning are participated in singing.Estrogens in the brain of songbirds are mainly estradiol(E2),which is transformed by neural testosterone(T)through aromatase.A series of important results were achieved in the regulation of estrogen on the central nervous system of songbirds,mainly focusing on the regulation of estrogen on auditory coding,brain damage repair,spatial memory and singing behavior of songbirds.The progress of estrogen regulation in the central nervous system of songbirds is discussed in this paper.