药用/工业用转基因植物数据库的构建

Construction of database of pharmaceutical and industrial transgenic plants

目的收集以植物作为生物反应器生产药用/工业用产品的数据信息,构建药用/工业用转基因植物数据库。方法收集药用/工业用转基因植物相关资料,每个转化事件收集包括外源蛋白表达量、毒性、致敏性、临床数据、安全等级在内的20多种信息。利用Linux.Apache Mysql PHP(LAMP)架构首次设计药用/工业用转基因植物数据库,面向用户不同需求设计初级检索和高级检索两种检索方式。结果本研究成功构建了药用/工业用转基因植物数据库。目前,收集了300多份数据信息,整理了转化事件近200条,完成信息上传108条,并将定期更新。结论该数据库具有综合性、专业性、实用性和首创性的特点,为药用/工业用转基因植物新品种的研发提供信息帮助,为政府机构审批和监管以及制定其安全评价标准提供技术支撑。

Objective To construct the database of pharmaceutical and industrial transgenic plants, the research group collected published data related with genetically modified (GM) plants as bioreactors. Methods Collect information associated with GM plants. Every GM event contains more than 20 parameters including the expression of exogenous protein, toxicity, allergenicity, clinical data and security level, etc. The database was designed with Linux Apache Mysql PHP (LAMP) and two kinds of retrieval modes, primary retrieval method and advanced retrieval method, were realized for different users. Results In this study, the database of pharmaceutical and industrial transgenic plants was constructed successfully. Presently, we collected more than 300 published data related with GM plants as bioreactors, compiled 200 GM events approximately and uploaded 108 GM events of the information. Conclusion The database is characterized by comprehensiveness, specialty, practicability and innovation, providing information resources for new GM plant varieties development and technological support for government to formulate regulations, approve and supervise pharmaceutical and industrial GM plants.