电感耦合等离子体质谱法测定霜状化妆品中铅、镉、铬、砷和汞

Determination of lead, arsenic, cadmium, chromium and mercury by inductively coupled plasma mass spectrometry in frost cosmetics

目的建立快速测定霜状化妆品中铅、镉、铬、砷和汞的分析方法。方法通过微波消解进行样品前处理,用电感耦合等离子质谱法同时测定霜状化妆品中铅、镉、铬、砷和汞。优化了仪器条件,进行了检出限、精密度和准确性等方法学研究。结果经过与《化妆品卫生规范》指定方法的比对验证,相关系数均>0.999,检出限在0.03μg/kg^0.12μg/kg之间,相对标准偏差(RSD)在3.5%~8.1%,回收率在96%~116%。结论用不同基质的有证标准物质进行验证,测定值均在标准值范围内,该方法适用于霜状化妆品中铅、镉、铬、砷和汞的快速测定,能够满足《化妆品卫生规范》要求。

ABSTRACT:Objective To establish a rapid determination analysis method of lead, cadmium, chromium, arsenic and mercury in frost cosmetics.Methods By microwave digestion for sample pretreatment, lead, cadmium, chromium, arsenic and mercury in frost cosmetics were directly determined by inductively coupled plasma mass spectrometry. The instrument condition was optimized and the methods detection limit, precision and accuracy of methodology were researched.Results With theCosmetics Health Standardcomparison verification method, correlation coefficient > 0.999, the detection limit was between 0.03μg/kg^0.12μg/kg, relative standard deviation (RSD) was 3.5%~8.1%, the recovery was 96%~116%.Conclusion Verified by the standard materials with different substrates, the measurements were within the scope of the standard, which showed the method was suitable for rapid determination of lead, cadmium, chromium, arsenic and mercury in the frost cosmetics, and could satisfy the requirements ofCosmetics Health Standard.