真菌中氧胁迫调控因子AP-1研究进展

Research progress on oxidative stress transcript factor AP-1 in fungi

氧化应激是细胞应激反应的一种,在所有生物中都是保守进化的。应激反应的调控包括转录、翻译和翻译后修饰,决定生物体是否适应、存活、或者死亡。酵母中b-ZIP型激活蛋白(Yap)家族包括8个成员,Yap1是酵母Yap家族中首先发现的成员,具有DNA结合结构域和转录激活活性,在细胞的氧化应激中发挥着必不可少的作用。在氧化压力下,Yap1的活性增加。本文对近年来AP-1转录因子在真菌中的主要研究进展进行了综述,重点介绍了AP-1作为主要的氧化应激调节器参与的生物学应激反应、致病性及产生真菌毒素等,并介绍了AP-1在铁代谢、钴毒性、DNA损伤、耐药性中的功能。

Oxidative stress, which is one of cellular stress responses, is evolutionarily conserved in all living organisms. The regulation of stress response includes transcriptional, translational and post-translational mechanisms, deciding whether the organism adapts, survives, or dies. The yeast activator protein(Yap) family of b-ZIP proteins consists of 8 members. Yap1, the first member of the Yap family to be found, has a DNA binding domain and transcriptional activation and is essential for the normal response of cells to oxidative stress. When it is under oxidative stress conditions, the activity of Yap1 will increase. In this paper, the main research progress in recent years on the AP-1 transcription factor in fungi was reviewed, focusing on AP-1 involving in biological stress response as the main regulator of oxidative stress, pathogenicity, and mycotoxin biosynthesis, and the function of AP-1 in iron metabolism, cobalt toxicity, DNA damage, and drug resistance was also be introduced.