乳糜泻中肠道微生物群的研究进展

Research advances in gut microbiota of celiac disease

乳糜泻是一种多因素疾病,其致病机制涉及遗传和环境因素之间的相互作用。麸质蛋白是导致乳糜泻症状的主要环境因素,目前有研究报道,影响乳糜泻患者肠道生态系统的其他环境因素主要为肠道微生物群的失衡,特别是与革兰氏阴性菌数量增加和革兰氏阳性菌数量减少有关。本综述详细介绍了乳糜泻的发病机制,并总结了口腔、肠道微生物群与乳糜泻之间的关联;利用现有研究解释微生物菌群在发病机制中可能的作用方式以及乳糜泻患者微生物菌群发生的变化。此外还将相关益生菌对乳糜泻疾病的调节作用加以介绍,进而帮助我们从人类肠道微生物群的角度深入探讨乳介绍糜泻的致病机制,探究肠道微生物群与麸质相关疾病之间的密切联系,并尽可能在近期开发出新的预防和治疗乳糜泻的策略。

Celiac disease is a multifactorial disease that involved the interaction of genetic and environmental factors.Gluten protein is the main environmental factor cause of celiac disease.At present,it is reported that other environmental factors affecting the intestinal ecosystem of patients are mainly the imbalance of intestinal microbiota,especially relate to the increase in the number of Gram-negative bacteria and the decrease in the number of Gram-positive bacteria.This review introduced the pathogenesis of celiac disease in detail and summarized the association between oral and intestinal microbiota and celiac disease with existing research to explain the possible role of microbial flora in pathogenesis and changes that occured in the microbiota of patients with celiac disease.In addition,the effects of probiotics on celiac disease were also introduced in this article.By helping us understand and study this autoimmune disease from the perspective of human gut microbiota,we will explore the close relationship between gut microbiota and gluten-related diseases,and identify new prevention and treatment strategies in the future as much as possible.