超高效液相色谱-串联质谱法测定婴幼儿化妆品中米诺地尔等7种成分

Determination of minoxidil and other 6 kinds of components in infant cosmetics by ultra-high performance liquid chromatography-tandem mass spectrometry

目的对市售婴幼儿化妆品中米诺地尔、氢化可的松、螺内酯、雌酮、坎利酮、醋酸曲安奈德、黄体酮7种禁用成分进行市场调研。方法以Atlantis dC_(18) (100 mm×2.1 mm, 2μm)为分析柱, 0.1%甲酸溶液-甲醇为流动相进行梯度洗脱后,采用超高效液相色谱-串联质谱电喷雾电离(ESI+)检测7种禁用成分。结果 7种标准溶液在10～600ng浓度范围内呈良好线性关系(r≥0.9990),加标回收率为92.6%～95.2%,相对标准偏差(relative standard deviations, RSDs)为2.1%～4.1%,对20批市售婴幼儿化妆品中米诺地尔等7种成分进行检测,结果均未检出。结论我省婴幼儿化妆品市场中米诺地尔等7种成分的市场现状相对良好。

Objective To investigate 7 kinds of banned ingredients(minoxidil,hydrocortisone,spironolactone,estrone,canalidone,triamcinolone acetate,and progesterone)in infant cosmetics on the market.Methods Seven kinds of banned ingredients were detected by ultra-high performance liquid chromatography-tandem mass spectrometry electrospray ionization(ESI+),using a column of Atlantis dC18(100 mm×2.1 mm,2μm),with the mobile phase of 0.1%formic acid solution for gradient elution.Results The 7 standard solutions showed good linear relationships(r≥0.9990)in the concentration range of 10-600 ng.The recoveries of the spiked concentrations were 92.6%-95.2%and relative standard deviations(RSDs)were 2.1%-4.1%.The 7 components in 20 batches of cosmetics for infants and young children were not detected.Conclusion The market situation of minoxidil and other 6 ingredients in infant cosmetics market in our province is relatively good.