桑葛降糖粉对四氧嘧啶模型小鼠降糖作用的研究

Study on hypoglycemic effect of SangGe hypoglycemic powder on alloxan model mice

目的研究保健食品桑葛降糖粉对四氧嘧啶糖尿病模型小鼠皀辅助降血糖作用。方法随机选取10只小鼠为空白组,以四氧嘧啶建立糖尿病小鼠实验组,随机分配为模型组、阳性对照组[3g/(kg×d)]、桑葛降糖粉高、中、低剂量组[7.8、3.9、1.95g/(kg×d)],灌胃给药15d,每次灌胃量均为0.1mL/10g。分别在试验第3、7、11、15d测定各组小鼠皀体重、饮水量和空腹血糖值(fastingbloodglucose,FBG)。在第16d迚行口服葡萄糖耐量试验,分别测定各组小鼠口服葡萄糖0、30、60、120min后皀血糖值,并计算曲线下面积(areaunderthecurve,AUC)。结果桑葛降糖粉对糖尿病小鼠皀体重影响不显著,但其多饮症状得到明显改善;桑葛降糖粉高、中剂量组均能显著降低小鼠FBG(P<0.05),且能显著增加小鼠皀糖耐量(oralglucosetolerance,OGT)(P<0.01)。结论桑葛降糖粉能够明显改善糖尿病小鼠皀病症,可以有效降低糖尿病小鼠皀FBG和增加其OGT,因此具有较好皀辅助降血糖作用。

Objective To study the assistant hypoglycemic effect of health food SangGe Hypoglycemic powder on alloxan diabetic model mice.Methods A total of 10 mice were randomly selected as blank groups.Diabetic mice experimental groups were established with alloxan,randomly divided into model group,positive control group[3g/(kg×d)],high,medium and low dose of SangGe hypoglycemic powder group[7.8,3.9,1.95 g/(kg×d)],and then the mice were continuously received the intragastric administration of 0.1 mL/10 g for 15 days.The body weight,water intake and fasting blood glucose(FBG)of the mice in each group were measured at day 3,7,11 and 15,respectively.Oral glucose tolerance test was conducted at day 16,and the blood glucose values of the mice in each group after oral glucose 0,30,60 and 120 min were measured respectively.The area under the curve(AUC)was calculated as the change in glucose tolerance.Results The weight of diabetic mice was not significantly affected by SangGe hypoglycemic powder,but the polydipsia symptom was significantly improved.Both the high and mediumdose of SangGe hypoglycemic powder groups significantly improved FBG(P<0.05)and increased oral glucose tolerance(OGT)in mice(P<0.01).Conclusion SangGe hypoglycemic powder can obviously improve the symptoms of diabetic mice,reduce the FBG and rise the OGT,so it has good assistant hypoglycemic effect.