益生菌缓解肥胖形成相关机制及研究进展

The Mechanism and Research Progress of Probiotics in Relieving Obesity

肥胖及相关代谢综合征已成为世界范围内的公共健康问题。研究表明,肠道菌群与肥胖的形成密切相关,肠道菌群失调导致脂代谢紊乱、肠道通透性及氧化应激等改变。益生菌(主要包括乳酸菌和双歧杆菌)是一类能对宿主生理功能产生有益作用的微生物,能在肠道中存活并定殖,改善肠道菌群紊乱,进一步缓解肥胖的形成。本文主要围绕益生菌对肥胖的干预作用及相关机制进行综述,以为肥胖相关的研究提供参考。

Obesity and related metabolic syndromes have become public health problems in the world. It has shown that intestinal flora is closely related to the formation of obesity,and dysregulation of intestinal flora could influence on lipid metabolism,intestinal permeability,and oxidative stress.Probiotics(mainly including lactic acid bacteria and bifidobacteria) are microorganisms that could have beneficial effects on the physiological functions of the host,survive and colonize the intestine,improve intestinal flora,and further alleviate the formation of obesity. In this paper,the intervention effect of probiotics on obesity and its related mechanisms were reviewed,so as to provide references for obesity-related research.