摘要
为优化葛根素白蛋白微球处方工艺。以牛血清白蛋白为载体,采用乳化热固化法制备葛根素白蛋白微球。以包封率和载药量为综合评价指标,以牛血清白蛋白用量、葛根素用量、司盘80用量为考察因素,在单因素实验的基础上,利用均匀设计法优化葛根素白蛋白微球的处方工艺。葛根素白蛋白微球最优处方为:牛血清白蛋白0.20 g,葛根素30.00 mg,司盘80为0.80 m L,验证处方的包封率为76.75%±2.09%,载药量为9.81%±0.14%。采用均匀设计优化法制备的葛根素白蛋白微球综合评分高,模型预测性良好。
To optimize the formulation of puerarin albumin microspheres. The microspheres were prepared by emulsion-heat stabilization techniques using albumin as carrier. The encapsulation efficiency and drug loading rate of the puerarin albumin microspheres were selected as comprehensive evaluation indexes.The amount of bovine serum albumin,the amount of puerarin and the amount of span-80 were selected as factors.Uniform design method were used to optimize the formulation process of puerarin albumin microspheres.Optimum formulation of puerarin albumin microspheres was as follows: Bovine serum albumin was 0.20 g,puerarin was 30.00 mg,span-80 was 0.80 m L.The entrapment efficiency of optimum formulation was 76.75% ± 2.09% and the drug loading was 9.81% ± 0.14%. The formulation process of the puerarin albumin microspheres optimized by uniform design method was effective and feasible with a good prediction,and the results showed a high comprehensive score.
作者
周婷
余彩英
吴卫
奉建芳
ZHOU Ting;YU Cai-ying;WU Wei;FENG Jian-fang(School of Pharmacy,Guilin Medical University,Guilin 541004,China;School of Pharmacy,Guangxi University of Chinese Medicine,Nanning 530200,China)
出处
《食品工业科技》
CAS
北大核心
2019年第4期141-145,共5页
Science and Technology of Food Industry
基金
国家自然科学基金项目(81760704
81573623)
广西自然科学基金项目(2016GXNSFAA380081)
关键词
葛根素
白蛋白微球
处方优化
均匀设计
puerarin
albumin microspheres
prescription optimization
uniform design