β-环糊精包埋柠檬醛微胶囊工艺优化及其缓释性能

Optimized Microencapsulation in β-cyclodextrin and Sustained-Release Properties of Citral

以β-环糊精为壁材,采用乳化法制备柠檬醛微胶囊,考察固形物质量分数、乳化剂质量分数和心壁比对柠檬醛微胶囊包埋产率和包埋效率的影响。采用响应面法对3个单因素工艺参数进行优化,回归得到二次多项式模型极显著,模型的相关系数为0.966 1,优化试验工艺条件为固形物质量分数26%、乳化剂质量分数0.8%和心壁比1∶4。在此条件下进行验证实验,柠檬醛微胶囊包埋产率值为78.8%。缓释性能实验结果表明,微胶囊化可以明显降低柠檬醛的挥发速率,Avrami’s方程也可以对柠檬醛微胶囊释放过程进行较好地拟合。

In this paper,citral microcapsules were prepared using β-cyclodextrin as wall material by emulsification. The yield and microencapsulation efficiency of microencapsulated citral were investigated as functions of solid content,emulsifier content and core-to-wall material ratio. The response surface methodology was employed to optimize the three process parameters. A quadratic polynomial regression model was established which was found to be highly significant and have a correlation coefficient of 0.966 1. The optimized experimental conditions were: solid content,26%; emulsifier content,0.8%; and core-to-wall material ratio,1:4,giving a yield of 78.8% in validation experiments. Meanwhile,the sustained-release properties of microcapsules were investigated by comparison with those of the free citral. The results showed that microencapsulation could slow down the release of citral. The release course of the microcapsules could be fitted well with the Avrami equation.