脂质组学及其在营养与健康研究中的应用研究进展

Lipidomics and Its Application in Nutrition and Health Research

脂质是生物体重要的大分子物质之一,结构和种类复杂,具有重要的生理功能。脂质代谢的异常可能引发诸如动脉粥样硬化等许多代谢疾病。脂质代谢组学是代谢组学的一个分支,是综合研究脂质代谢的一个重要手段。随着质谱与色谱联用技术的发展,脂质组学也得到快速发展。利用脂质组学研究脂质分子在代谢疾病中的作用受到越来越广泛的关注。本文主要介绍了脂质组学的研究方法,及其在人体脂质代谢疾病中的应用和研究进展。

Lipids, compounds with complex structures and classes, are one important class of biomacromolicules in organisms. Abnormal lipid metabolisms may lead to many metabolic diseases, such as atherosclerosis. Lipidomics, a sub-branch of metabonomics, is an important approach aiming at comprehensive analysis of lipid metabolisms. Recent advancements in mass spectrometry combining with chromatography have led to the rapid development of lipidomics. Investigating the role of lipid molecules in metabolic diseases has attracted increasing attention. In this review, we focus on the analytical approaches in used in lipidomics research, and recent advances in their applications in the field of nutrition and health.