紫薯花青素降血脂及抗氧化效果

Hypolipidemic and Antioxidant Effects of Anthocyanins from Purple Sweet Potato in Rats

研究紫薯花青素(anthocyanins from purple sweet potato,PSPAs)对高血脂大鼠的血脂水平和抗氧化能力的影响,并对其主要成分进行分析。将Sprague-Dawley(SD)大鼠分为空白组和高脂组,分别喂养基础饲料和高脂饲料4周,测定其体质量及血脂水平,判断大鼠高血脂模型是否建立成功。再将建模成功的高脂组大鼠分为模型组、阳性对照组和PSPAS低、中、高剂量组,测定大鼠体质量及脏体指数、血清中血脂水平、肝组织中的超氧化物歧化酶(superoxide dismutase,SOD)活性和丙二醛(malondialdehyde,MDA)含量。结果表明,PSPAs对大鼠体质量、肝脏指数和脾脏指数的增加有一定的抑制作用,而可以提高心脏指数;PSPAs能降低高血脂大鼠血清总胆固醇、甘油三酯、低密度脂蛋白胆固醇、载脂蛋白B水平,降低动脉粥样硬化指数(atherosclerosis index,AI)AI_1、AI_2和肝组织中NMA的含量,能提高大鼠血清高密度脂蛋白胆固醇、载脂蛋白AI含量和肝组织SOD活性,其中以PSPAs高剂量组的降脂作用和抗氧化效果最好。以上结果表明PSPAs有降低大鼠血脂、抗氧化作用。

The hypolipidemic and antioxidant effects of anthocyanins from purple sweet potato(PSPAs) were evaluated.SD rats were divided into two groups which were fed with normal diet and a high-cholesterol diet for four weeks,and then the body weights and serum lipid profile were determined to examine whether hyperlipemia model was successfully established.Then,the rats from the high-cholesterol diet group were divided into 5 groups including model group,positive control group,and low-,medium-and high-dose anthocyanins groups.The levels of serum lipids,the activity of SOD and the content of MDA were measured.The results showed that PSPAs significantly inhibited the body weight gain and the increases in liver index and spleen index,but enhanced heart index.The levels of serum TC,TG,LDL-C and Apo B,atherosclerosis index and liver MDA level in hyperlipidemia rats fed with PSPAs were significantly lower than those in the model group.In addition,PSPAs increased serum HDL-C and Apo A I and the activity of SOD in liver.The best hypolipidemic and antioxidant effects of PSPAs were observed when used at high dose.